ANTIOXIDATIVE THERAPY: NANOTECHNOLOGY PRODUCT TMA-ZEOLITE REDUCES OXIDATIVE STRESS IN CANCER AND DIABETIC PATIENTS
MEDIGENCE LLC, Chapel Hill, USA
Reactive free radicals derived from oxygen have been implicated in numerous pathological processes including inflammation, reperlusion injury, hemorrhagic shock, autoimmune diseases, neurological disorders, diabetes mellitus and cancer. Objective of this study was to determine whether tribomechanically activated zeolite (TMA-Zeolite) with the strong antioxidative properties could affect oxidative stress in cancer and diabetes patients.
Blood samples were taken prior to and one month after continu- ous intake of TMA-Zeolite from 114 cancer (53 G.l. 40 lung, 21 brain tumors) and 62 diabetes patients. The Flandox Total Antioxidant Status (TAS) kit was used to determine antioxidant levels of superoxide dismutase, glutathione peroxidase and glu- tathione reductase. Free radical analytical system (F.Ft.A.S.) was used to determine antioxidant effect of TMA-Zeolite.
In cancer patients, a mean TAS prior to TMA-Zeolite treatment was 1.23 mmollL. One month after beginning oiTMA-Zeolite ther- apy there was a significant increase of 42% (p<0.01) in the circu- latory antioxidant levels. At the same time the mean F.Fl.A.S. val- ues dropped by 26.5 % (p<0.05). ln diabetic patients TAS levels prior to treatment was 1.26 mmoVL and increased to 1.47 mmol/L after one month of TMA-Zeolite intake. The smaller (15%) increase in TAS in diabetic patients is most likely due to the lower (60 %) doses of TMA-Zeolite given to diabetic patients as com- pared to cancer group of patients. These results have shown strong antioxidative properties ol TMA- Zeolite and its ability to reduce oxidative stress in patients suffer- ing from malignant diseases or diabetes.
Preliminary results also indicated an association between the decrease in oxidative stress and an improvement in the clinical status and the quality of life. These findings, however, require future clinical testing.
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